Microdosis – Reparar el cerebro, cámara hiperbárica, tanques de aislamiento sensorial – proveedores Quito.


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One of the Biggest Dangers of Microdosing is Accidentally Macrodosing

Sara Gael, director of harm reduction at the MAPS Zendo Project, an organization committed to supporting people going through bad psychedelic trips, on the best ways to ride it out.

Move the body
“Qi Gong, yoga, stretches like that can be helpful; they get energy moving. When we’re really stuck in our head, feeling comfortable in our body can help.”

Eat something
“This can instantly help you feel grounded.”

Go outside
“Being in nature is a big one. Go to the park; it doesn’t have to be in the middle of nowhere, though still try to avoid a ton of people.”

Put on some music
“Something instrumental — classical, piano, guitar; mellow is key.”



When it comes to the benefits to wellbeing, psilocybin is a driver for personal growth. In the hours, days, and weeks following a magic mushroom journey, people feel capable of overcoming challenges, moving through past trauma, and pushing through mental health issues. Even microdosing can stimulate clearer focus, positive changes to mood, and boost creativity.

On the therapeutic end of the spectrum, there are dozens of clinical trials underway examining the potential of psilocybin for mental health applications. Several of these studies, either in the recruitment phase or already underway, are exploring psilocybin for major depressive disorder, anorexia nervosa, obsessive-compulsive disorder, among other targets. Completed clinical studies have found immense benefits for alleviating fear and anxiety associated with a terminal diagnosis, spiritual practice, and changes to mood.


0.05 to 0.25 grams
A microdose is the smallest possible dose and used primarily for therapeutic purposes targeting general wellbeing. For most people, the goal of microdosing psilocybin is not to experience the psychedelic trip, but solely to reap the therapeutic benefits. A starting microdose is roughly 0.05 to 0.25 grams of psilocybin (each person will have their own tolerance level). You should not expect any visuals or physical effects from a microdose. However, you may experience heightened senses, emotions, or a feeling of introspection. These effects may only become apparent the following day.


1 to 2 grams

This is the typical suggested dose for recreational tripping and as a starter therapeutic target. Expect elevated emotions, introspective periods, and an altered psychological state of being are often likened to a dreamlike state.

This standard dose will seemingly disrupt the passage of time, stimulate mild visuals, and sometimes lead to synesthesia. Commonly reported visuals include halos, geometric patterns, tracers, breathing, and vivid colours. You may also feel intense emotions, both good and bad, which may lead to a growing sense of acceptance, calmness, and connection to those around you and/or nature.


2 to 3.5 grams

A therapeutic dose starts at roughly two grams, and is when a true psychedelic experience begins. This includes visual hallucinations, physical effects, and often lifechanging breakthroughs. Trip sitters and space holders may be necessary at this dose, depending on the purpose.

All the common effects of a standard dose also happen with a therapeutic dose, but with much more intensity. Although you will be aware of your surroundings, a therapeutic dose can become overwhelming. Expect powerful introspection, philosophical thoughts, waves of sensations (good and bad), visuals, and difficulty with cognitive tasks.

A therapeutic trip typically lasts between four to six hours, with the peak around two hours in. Benefits may last days, weeks, or months later.


5 grams or more

Best suited to those working with an experienced healer, psychiatrist, or space holder, a heroic dose is a powerful spiritual journey. A heroic dose creates overwhelming sensations, strong visualizations, and can have life long impact. Common experiences include ego death, feelings of mystical wonder, connection to the divine, and lifechanging breakthroughs. Side effects may include disorientation, confusing visualizations, acute anxiety or fear, and compromised motor functions.

A therapeutic trip typically lasts for at least six hours, with the peak around two to three hours in. Benefits may last weeks, months, or years later.



What it is: “Magical mushrooms” contain the psychoactive compound psilocybin. They can be eaten, brewed into tea, or coated with chocolate.

How microdosing it feels: About an hour or two after ingesting the microdose, people notice an increase in focus and energy. Many users find that it helps with weaning off — and staying off — anti-depressants. It can help lessen the side effects of withdrawal and even mitigate depression. Many speak to the drug’s ability to increase empathy, too.

Mushrooms: “Like LSD, it makes me feel in the moment, and my day-to-day feels fresher and less stale. The main difference is that it’s shorter and less energizing. It makes me feel more ‘go with the flow’ and less analytical and sharp.”


What it is: Cannabis is a psychoactive drug from the cannabis plant. It’s either smoked, vaporized, or taken in tinctures or edibles.

How microdosing it feels: Cannabis in microdose form has been found to be helpful for a wide variety of physical ailments: chronic pain, nausea, inflammation, indigestion, fibromyalgia, PTSD-associated insomnia, even nightmares. But it also helps with mood: It can boost interest in one’s surroundings, creativity, happiness, and focus, while also combating stress.

CBD: “I take CBD — the non-psychoactive element of cannabis — every day to help calm my mind and body. I microdose Mr. Moxey’s Mints when I need a little kick or I get stuck in a bad thought loop at work. It’s less impactful per dose than LSD, but I owe being able to function in a 40-hour workweek to them.”


What it is: An Amazonian plant mixture that contains the psychoactive substance DMT. It’s generally consumed in a tea.

How microdosing it feels: Microdosing ayahuasca can increase sensitivity and openness in users — many feel their boundaries and defenses dissolve. It is not optimal for work, as it can make physical and mental tasks slightly more strenuous and can make users feel passive — “It made it hard to answer emails, write queries, research,” said one.


San Pedro

What it is: A cactus that contains the psychoactive substance mescaline. It’s generally consumed in a tea.

How microdosing it feels: Microdosing San Pedro is like a massage from the inside. It reprograms the organic systems, promoting detox and energy flow. It improves a warm fulfilment feeling and relaxation, recomforting wholeness, and sensitivity.


What it is: An Amazonian plant mixture that contains the psychoactive substance DMT. It’s generally consumed in a tea.

How microdosing it feels: Microdosing ayahuasca can increase sensitivity and openness in users — many feel their boundaries and defenses dissolve. It is not optimal for work, as it can make physical and mental tasks slightly more strenuous and can make users feel passive — “It made it hard to answer emails, write queries, research,” said one.


What Scientists Say about Microdosing Psilocybin

As of November 2019, there are very few rigorous, scientific studies on the effects of microdosing psilocybin. This is largely due to the regulations surrounding the study of psychedelic substances. However, scientists have collected anecdotal evidence to support their desire to further study the potential benefits and risks of microdosing. One study interviewed 21 individuals microdosing psilocybin mushrooms on a regular basis. This study found that the users reported “mostly positive consequences” with effects including an improved mood, cognition, and creativity.

How to Microdose Psilocybin

In the psychedelic community, microdosing psilocybin means consuming a very small dose of psilocybin mushrooms every third or fourth day. Typical doses range from 0.10 grams to 0.25 grams of dried P. cubensis mushrooms. Most users will pulverize the mushrooms into a powder, weigh out doses, then store those doses in size 00 capsules for later use.

Paul Stamets created a unique microdosing technique he calls “stacking.” It involves a combination of niacin, Lions Mane, and P. cubensis. This method combines approximately 0.1-1 gram of P. cubensis, 5-20 grams of Lions Mane, and 101-200 milligrams of niacin. His belief is the niacin enhances the effects of the psilocybin while reducing the psychedelic experience.

Small Doses

Small doses of psilocybin, referred to as a “microdose,” do not produce any acute effects, but rather a psychological and social benefit from regularly consuming microdoses. These effects include increases in:

  • Alleviated symptoms of depression and anxiety
  • Enhanced productivity
  • Improvements in overall well-being
  • Enhancements in convergent and divergent thinking

Large doses

When consumed in large doses, psilocybin produces a profound psychedelic effect involving:

  • Closed and open eye visuals
  • Dilated pupils
  • Reduced appetite
  • Euphoria
  • Heightened emotions
  • An altered sense of reality.


Microdose – 1-2ml before bed

No psychedelic effects. Restful sleep. Energized the following day.

Light – 30ml

Ego tendencies are still present. Ability for cognitive and rational thinking. Motor skills are still somewhat functional (ability to walk). Some mild to strong visuals.

Medium – 50ml

Potential for full experience. Purging, possible ego dismantling.

Heavy – up to 70ml

Full surrender. Concepts and ego dissolves. Limitless space of potential. Purging.“Microdosing can be used to regenerate cells or activate the pineal gland and the immune system.  What you try to accomplish depends on your approach.  For me it is about being healthy with a clear mind.” – Raimutsa.

How Ayahuasca Works Inside Your Body.

N,N-dimethyltryptamine (DMT), is a psychedelic substance that occurs naturally in the plant Psychotria viridis. Because of the low bioavailability of DMT in the plant it is quickly broken down by enzymes (monoamine oxidases) in your liver and gastrointestinal tract. These enzymes are often referred to as MAOs. Because of these digesting enzymes, MAO inhibitors are needed to prevent the DMT from being flushed from the body. Banisteriopsis caapi is a thick vine that contains β-Carboline, MAO-inhibiting enzymes. These enzymes not only inhibit MAOs but have psychoactive effects of their own. When combined, these two plants create ayahuasca, the sacred traditional drink used in ceremony that has powerful psychedelic properties. This brew affects the central nervous system, creating out-of-body experiences and an extreme state of altered consciousness.


When microdosing mescaline, suggested dosage is between 10–30 mg.

For a mild psychedelic experience, ingesting 200 to 300 mg of mescaline is recommended.

For a strong psychedelic trip, 300 to 500 mg is suggested.

Finally, for a “hero dose,” 1,000 mg and up is recommended.

What to Know Before Microdosing San Pedro

When microdosing San Pedro it is important to know the source of your product. If you are new to microdosing or to psychoactive plants, it is wise to start at the lowest level of recommended dosage and work your way up. Microdosing San Pedro oftentimes requires patience and observation for an individual to find their “sweet spot.”

Common Effects When Microdosing San Pedro

Microdosing San Pedro is helpful for a number of reasons. The neurotransmitters that mescaline activates affect how we feel, and how we process information. This is extremely beneficial and can help with a number of emotional struggles. It can also increase beneficial brain activity for success in your career, personal relationships, and level of self-contentment.

Short-Term Benefits of Microdosing San Pedro Include:

  • Reduced Anxiety
  • Higher Energy Level
  • Improved Mental Focus and Clarity
  • Adaptability
  • Improved Organ and Body Function
  • Enhanced Fluency of Ideas
  • Improved Creativity (ability to think outisde the box)
  • Heightened Empathy
  • Heightened Sociability

Long-Term Benefits of Microdosing San Pedro Include:

  • Ability to Reprogram Automatic or Unhealthful Behaviors
  • Focus on Personal Health (San Pedro becomes a part of the healthy diet)
  • Self Reflection
  • Clarity for Personal Intention

San Pedro brew contains a higher concentration than powder. It is important to know where the brew is from, and to be certain not to mix it with anything else. Brews can range in concentration so dramatically that a suggested microdose can be anywhere from 1 ml (one tincture dropper) to 30 ml. The schedule for microdosing San Pedro should be adapted on a case-by-case basis, but suggested dosage is at breakfast 5–6 days a week; then rest to digest 1–2 days without San Pedro, before starting over again.

Like Raimutsa, some may choose to dose twice a day, once with breakfast and again at lunch if they are planning a late night of work. The two days off are important to allow the body to rest and digest the medicine. This is a time for reflection, as well as providing time for the body to start producing new neurotransmitters in the brain. Microdosing San Pedro is done with the intention of developing a sensitivity to the medicine, eventually lowering your dose while still receiving the same benefits. The idea is to increase the level of neurotransmitters in the brain, and reap the benefits. This takes a while and one must be patient.

Long breaks are necessary when microdosing San Pedro. The recommended length of sessions is 34 months. During the month-long break without the medicine, an individual has time to reflect on the experiences and personal growth. These breaks are important for your body, and to give yourself time to observe the effects of the medicine.

Common Interactions When Microdosing San Pedro

No research is available on the topic of mixing microdosed amounts of San Pedro with other substances. In general, do not mix alcohol with mescaline.

How Much San Pedro Causes an Overdose?

San Pedro is considered one of the safest psychoactive plants. There have been no reports of deaths linked to thousands of years of shamanic use. A person would have to ingest such a large quantity of San Pedro to make it lethal that it would not likely happen by accident.


Welcome to the microdosing blog series, in which we tell you everything about taking small amounts of psychedelics in a number of articles. Quickly navigate to the other blogs in this series:

Taking a gramme of Magic Truffles. What does that do to you? Just like shrooms, Magic Truffles contain the active substances psilocybin, psilocin, baeocystin and norbaeocystin. A whole mouthful of chemistry. But that is not the intention. A small quantity of these nodules which grow underground promises a weekly routine with more focus, energy and creativity but people also report that they make progress in terms of anxieties, experience enhanced activity of all their senses and a deep appreciation for spirituality.

How does Microdosing psilocybin work?

Back to the science. The substance we mentioned earlier, namely psilocybin, replicates the effect of our body’s own hormone, serotonin. That is putting it very succinctly and a bit more explanation is required. Classic psychedelica like psilocybin fit like a key to the lock of a serotonin receptor with the cheerful name of 5-HT2A. That is the receptor which mainly occurs in the prefrontal cortex in our brains. Stimulation of this receptor strengthens perception, the mechanism for learning and the memory. But it also stimulates brain activity, cell growth and an increase in the connections in the brain.

Psychedelica cause parts of the brain to talk to each other which normally have no interrelationship. That can happen because the so-called DMN (Default Mode Network) is put on a low setting.

This part of the brain causes us to daydream and end up time after time on the same mental path. Over-analysing and ducking away from the here and now is precisely what psychedelica temporarily switch off, creating space for direct impulses. The result? Colours become more intense, thought patterns change and break open, and you feel more connected to everything around you.

How often for Microdosing?

With Magic Truffles you build up a tolerance. Before very long you therefore need more and more for the same effect. In other words: they lose their immediate power after the first use. This is partly why Magic Truffles and shrooms are not addictive. The effect will return after a few days. Dr. James Fadiman, the author of the Psychedelic Explorer’s Guide recommends taking one dose every three days.

Take a dose on day one. On day two you are still having a few after effects and day three is a normal day. On day four you take a second dose and on days five and six you again do not.

What if you take more than 1 gramme of Magic Truffles? Then there’s a chance that the wall will show patterns all at once, the lamp will start smiling at you or the painting will suddenly splash colours.

Normally 5 grammes is mentioned as a low dosage for a trip.

How long can you continue with Microdosing?

There are people who keep up the rhythm without suffering any health complaints. But there is an increased risk of heart problems associated with prolonged use of psychedelica. That was established at higher doses and yet it’s best to play it safe, isn’t it?

You can do microdosing once in a while but don’t make a habit of it like you would drinking coffee. Psychedelica are potent substances which call for respect so use the knowledge from this article responsibly.

Never use psychedelica (not even a microdose) when you are taking medicine. In particular, antidepressants can be dangerous in combination with Magic Truffles. So don’t combine truffles with medication. Don’t mix with alcohol or other psychedelica or things will spin out of control rather quickly.

Psilocybin lets you explore all kinds of new connections in your brain [2]. That’s why, during an intense trip, you can sometimes taste colors and see sounds, but you also get all kinds of crazy thinking. The mechanism that normally manages the data traffic up there is turned off for a while.

The idea of microdosing with magic truffles or magic mushrooms is that you help your brain to create new pathways without it bothering you. With the right microdose of psilocybin you have no visual effects, but you feel more creative and energetic.



How Does Mescaline Work?

With mescaline, you cannot get off your head to such an extent as with the so-called ‘classic psychedelics, DMT, LSD and psilocybin (the active substance in shrooms and magic truffles).

  • Reduced inhibitions and fear (of failure).
  • Ability to deal with ideas more fluently
  • The ability to view problems from a broader perspective
  • Enhanced empathy with other people
  • Enhanced fantasy and imaginary powers
  • Enhanced feeling for the ‘eureka!’ moment [1]

Effects of Microdosing

Microdosing with tiny amounts of psychedelics is done to acquire some positive traits. And do so without hallucinating.

  • Elevated mood
  • Mental acuity / Enhanced focus
  • Self-reflection
  • Reduced craving for addictive substances
  • Enhanced creativity
  • Improved empathy
  • You become more extroverted and sociable
  • Increased energy and motivation [2]

Microdosing with Peyote or San Pedro – How much do you need?

You don’t need very much for peyote or san pedro microdosing. That’s because microdosing with cacti which contain mescaline is particularly awkward. One of the reasons is that the amount of mescaline contained varies from one cactus to another. And we’re not referring to different cactus species. One peyote may contain (a lot) more mescaline than another which is growing next to it.

Microdosing Schedule

Have you organised it and are starting to microdose? In that case, consider the following points:

  1. Mescaline works for longer (up to 24 hours) than psilocybin in Magic Truffles and Shrooms (up to 6-7 hours). It’s therefore more difficult to choose the right moment for microdosing with cacti. In any case, start early in the day so you are able to sleep properly that night. [3]
  2. In the same way as any psychedelic that affects the serotonin receptors, you soon build up a tolerance to mescaline. This means that the chance of addiction is very slight and that there is no point in taking peyote or san pedro for a long time. You therefore need to allow a few days interval between microdoses.
  3. The tolerance is interchangeable. That means that it makes no difference which psychedelics you use. After using peyote or san pedro for a few days in a row you have the same tolerance for other shrooms, LSD, LSA, DMT and 2C-B.

Safety First

You mustn’t microdose with psychedelics for too long. Definitely not for more than a couple of months in a row. This is because there are indications that long-term use of psychedelics can be bad for your heart. It’s difficult to dose mescaline from cacti so you should definitely not drive if you are experimenting with peyote or san pedro.


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Gold standard microdosing protocols…36:23

  • Psychedelics have tolerance, the reverse of addiction
  • Fadiman Protocol (2-day effect): 1 day on, 2 days off, 1 day on; (on microdosingpsychedelics.com)
  • Stamets Protocol: 4 days on, 3 days off; or 5 days on, 2 days off
  • A study to determine the difference between the two is currently underway
  • Jim does not recommend a “rotational” protocol where a different substance is taken each day
  • Go for the max benefit with the least amount you take
  • The best results are reported when taken less often




Microdosing Expert James Fadiman on the «Fadiman Protocol»


Stacking’ Lion’s Mane protocol goes as follows:

  • DAY 1 to 4 Stacking
  • DAY 5 to 7 Rest So no ingestion
  • DAY 1 – 4 Stacking
  • DAY 5 to 7 Rest
  • Up to 1 month
  • RESET: 2 to 4 weeks rest

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